Hepatitis delta infections.

Is Hepatitis Delta infections important in Brazil?

BACKGROUND The Hepatitis Delta Virus (HDV) can increase the incidence of fulminant hepatitis. For this infection occurs, the host must also be infected with Hepatitis B Virus. Previous studies demonstrated the endemicity and near exclusivity of this infection in the Amazon region, and as a consequence of the difficulty in accessing this area we used dried blood spots (DBS) in sample collection....

Delta hepatitis: an update.

Hepatitis delta virus (HDV) is a unique defective RNA virus that requires the helper function of hepatitis B virus (HBV), which provides the essential coat protein for virion assembly and propagation. It is the smallest animal virus and the only one to possess a circular RNA genome, as seen in plant viruses. HDV has evolved into three major genotypes that differ in their geographic distribution...

Therapy of Delta Hepatitis.

Delta hepatitis is the less frequently encountered but most severe form of viral hepatitis. Acute delta hepatitis, as a result of coinfection with hepatitis B and hepatitis delta, is rare, but may lead to fulminant hepatitis, and no therapy exists for this form. Chronic delta hepatitis (CDH) mostly develops as a result of superinfection of a hepatitis B surface antigen (HBsAg) carrier with hepa...

Construction and Eukaryotic Expression of Recombinant Large Hepatitis Delta Antigen

Background: Hepatitis delta virus (HDV) is a subviral human pathogen that exploits host RNA editing activity to produce two essential forms of the sole viral protein, hepatitis delta antigen (HDAg). Editing at the amber/W site of HDV antigenomic RNA leads to the production of the large form (L-HDAg), which is required for RNA packaging. Methods: In this study, PCR-based site-directed mutagen...

treatment of chronic delta hepatitis